Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trialRandomized Controlled Trial Published on 2022-12-012022-10-05 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 임상, [키워드] antiseptic mouthwashe cell cultures cetylpyridinium chloride clinical trial COVID-19 COVID-19 patients Culture double-blind Effect evaluated Evidence in vitro in vivo indicated Infectivity Mouthwash mouthwashe mouthwashes not affected Placebo placebo-controlled clinical trial quantitative PCR Randomized reduce reduced reducing Saliva Saliva. salivary SARS-CoV-2 shown significantly tested viability viral infectivity Viral load Viral transmission virucidal [DOI] 10.1080/22221751.2022.2098059 PMC 바로가기 [Article Type] Randomized Controlled Trial
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity vaccine immunogenicity. variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution substitution. T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
Murine Hepatitis Virus, a Biosafety Level 2 Model for SARS-CoV-2, Can Remain Viable on Meat and Meat Packaging Materials for at Least 48 HoursArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] biosafety Biosafety Level 2 bottleneck BSL2 Can condition conditions contribute coronavirus Coronaviruses COVID-19 case creating detectable determine Evidence facilitate Factor FIVE highest hour hpi hygiene inoculated involved material meat MHV Model murine hepatitis virus notable outbreak packaging material. Particles persistence physical physical distancing plant provide reduction reduction in reservoir resulting SARS-CoV-2 Spread spread of COVID-19 steadily decreased Styrofoam survival tested unpaired t test viability Viable viral infectivity virus [DOI] 10.1128/spectrum.01862-22 PMC 바로가기
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variantsArticle Published on 2022-10-062022-11-16 Journal: Cell Stem Cell [Category] COVID19(2023년), SARS, 변종, [키워드] cause Cell Cluster Dengue dengue virus disease-associated functional variant genome-wide association Genome-wide association study GWAS Human genetics identify indicated individuals Infection iPSC array isogenic hiPSC lines leakage of mtDNA locus Loss mitochondrial mtDNA NDUFA4 non-risk allele polymorphism provide risk risk allele SARS-CoV-2 SARS-COV-2 infection screening strategy sensitivity Signaling single-nucleotide single-nucleotide polymorphism SNP SNPs Stress susceptibility type I interferon type I interferon. upregulation viral infection viral infectivity virus Zika virus ZIKV [DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기
Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and releaseArticle Published on 2022-10-012022-11-15 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome assays Beta changed coronavirus Delta delta VoCs drug resistance drug response ENhance Evolution of SARS-CoV-2 genomes immune evasion inhibitor manifested Mutation novel antiviral drugs Protein provide quantification released remained Remdesivir replicon RNA S gene SARS-CoV-2 sgRNA supernatant Support Transcription variants variants of concern variants of concern (VOC) viral genome replication viral infectivity viral life cycle viral propagation Viral protein Viral-like particle (VLP). viral-like particles virion assembly VLP VoC VOCs WIV04 strain [DOI] 10.1016/j.virs.2022.06.008 PMC 바로가기
Antimicrobial peptides: features, applications and the potential use against covid-19Article Published on 2022-10-012022-11-16 Journal: Molecular biology reports [Category] 변종, [키워드] accelerated addition AMP AMPs Antibiotics antimicrobial antimicrobial peptides APD Bacteria biosynthesis pathway Cancer cells cationic clinical trial conserved COVID-19 demonstrated develop drugs Evolution Features functional fungi Innate immunity mechanism mechanisms peptide provide specificity therapeutic Therapeutic agents. Toxicity unique variants viral infectivity viruses [DOI] 10.1007/s11033-022-07572-1 PMC 바로가기
Effectiveness of Commonly Used Contact Lens Disinfectants Against SARS-CoV-2SARS-CoV-2에 대한 일반적으로 사용되는 콘택트 렌즈 소독제의 효과Article Published on 2022-09-012022-09-11 Journal: Eye & contact lens [Category] SARS, 치료기술, [키워드] absence acute respiratory syndrome Against applied Chain Reaction Contact contact lens detect disinfectant Disinfection Efficacy FIVE for disinfection Len PCR polymerase chain polymerase chain reaction regimen responsible reverse-transcriptase polymerase chain reaction rinsing RT-PCR SARS-CoV-2 SARS-CoV-2 RNA Severe Acute Respiratory Syndrome Corona Virus silicone tested time interval viability viral infectivity virus was tested were infected were used [DOI] 10.1097/ICL.0000000000000925 PMC 바로가기 [Article Type] Article
Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approachArticle Published on 2022-09-012022-11-15 Journal: Microbial pathogenesis [Category] SARS, 유전자 메커니즘, 치료제, [키워드] addition African Analysis Antiviral compound antiviral target approach binding energy calculate Cell cellular entry characterized Compound conformational database demonstrated disrupt distribution expressed feature functional In-vitro inhibitory effect Interaction mechanism of action molecular molecular dynamic simulation Molecular dynamics simulation multiple organ natural natural product Neuropilin-1 NRP1 performed pleiotropic Protein recent S-protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 research screened selected South stability surface receptor the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach viral infectivity virtual screening. [DOI] 10.1016/j.micpath.2022.105701 PMC 바로가기
Viral isolation allows characterization of early samples of SARS-CoV-2 lineage B1.1.33 with unique mutations (S: H655Y and T63N) circulating in Southern Brazil in 2020Article Published on 2022-09-012022-11-16 Journal: Brazilian journal of microbiology : [publication o [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] amplify approach B.1.1.33 Brazil circulating collected Complete coronavirus disease COVID-19 described elicit evaluate Genome H655Y help IMPROVE Isolation knowledge Lineage Mutation naso-oropharyngeal swab Next-generation sequencing NGS pandemic S:H655Y S:T63N SARS-CoV-2 SARS-CoV-2 lineage sequenced Southern Brazil. Spread unique viral infectivity viral stock virus [DOI] 10.1007/s42770-022-00789-z PMC 바로가기